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Although acanthosis nigricans is associated with high levels of insulin (insulin resistance), it can also occur with high levels of other growth hormones such as DHEAS, growth hormone, IGF-1 and testosterone. It typically occurs at areas of skin flexure (like the arm pits or under the breast). I'm p...

Hey there -- Nora has a congenital form of adrenal hyperplasia which results in a buildup of adrenal androgens. These issues typically arise earlier in life, depending on the severity of the enzyme deficiency and, therefore, symptoms (more severe deficiency means symptoms appear earlier in life). In...

hey no prob dawg I do this stuff for a living, lol.

Ryan

hey there... I wouldn't worry too much about your uric acid. It really takes lots and lots of protein over many years to actually develop gout if you don't have a genetic defect in xanthine oxidase (overactive). It was actually a disease of royalty in the old days (they were the only ones able to af...

The drug we use to treat gout or tumor lysis syndrome is called "allopurinol", which is a drug that inhibits the enzyme xanthine oxidase. The enzyme converts xanthine (an excretable substance) to uric acid. Diets very high in proteins cause a buildup in uric acid, which then precipitates i...

Hey Nora -- Congrats on doing so well with your diet! 7kgs/6 weeks is a healthy way to do it. A few things... For cholesterol, the general goal is LDL below 100 and HDL above 50. But remember, these things don't happen overnight! You're definitely headed in the right direction. Hopefully your doctor...

That's great! Definitely let us know how everything goes. I'm glad I was able to clear a few things up for you anyway :) The point about diabetes mainly applies to long term treatments of cortisone. There are other adrenal problems that predispose to diabetes, such as Cushing Disease (not to be conf...

The most common cause of these issues are likely anxiety or depression. These can cause slow-thinking, forgetfulness, lack of interest and other symptoms. The best thing you can probably do is just talk to your doctor about it. Antidepressant medications are excellent these days! SSRIs and SNRIs are...

Genetics could be part of it...but it's easy to chalk everything up to genetics... It sounds to me like your friend has been working his arms more than his chest. He may have worked his arms so much that his chest now looks smaller. It is HIGHLY unusual for a lack of muscle development in one specif...

Hey guys -- The majority of the cholesterol found in our bodies is MADE INSIDE THE BODY. Very little of dietary cholesterol actually makes it into cells. That's why the "statin" drugs are so useful for lowering LDL cholesterol. The mechanism of action is that they act on the actual DNA str...

Hello! Very interesting post about CAH... The main problem with CAH is that there is an enzyme deficiency (usually 21-alpha-hydroxylase) that is usually present in the adrenal glands. This enzyme is what allows us to produce a hormone called "aldosterone", which is responsible for potassiu...