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Sugar Substitutes - Neohesperidine Dihydrochalcone
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Neohesperidin dihydrochalcone, sometimes abbreviated to neohesperidin
DC or simply NHDC, is an artificial sweetener derived from citrus.
Chemical structure of hesperidin dihydrochalconeNHDC was discovered
during the 1960s as part of a United States Department of Agriculture
research program to find methods for minimizing the taste of bitter
flavorants in citrus juices. Neohesperidin is one such bitter compound.
When treated with potassium hydroxide or another strong base, and
then catalytically hydrogenated, it becomes NHDC, a compound roughly
1500-1800 times sweeter than sugar at threshold concentrations;
around 340 times sweeter than sugar weight-for-weight. Its potency
is naturally affected by such factors as the application it is used
for, and the pH of the product.
Like other highly sweet glycosides, such as glycyrrhizin (from
the licorice root) and those found in stevia, NHDC's sweet taste
has a slower onset than sugar's and lingers in the mouth for some
time. Unlike aspartame, NHDC is stable to elevated temperatures
and to acidic or basic conditions, and so can be used in applications
that require a long shelf life. NHDC itself can stay foodsafe for
up to five years when stored in optimal conditions.
The European Union approved NHDC's use as a sweetener in 1994.
It has not been approved as a sweetener in the United States, although
it is considered a Generally Recognized as Safe "flavour enhancer."
It is particularly effective in masking the bitter tastes of other
compounds found in citrus, including limonin and naringin. Industrially,
it is produced by extracting neohesperidin from the bitter orange,
and then hydrogenating this to make NHDC.
The product is well known for having a strong synergistic effect
when used in conjunction with other artificial sweeteners such as
aspartame, saccharin and acesulfame potassium, as well as sugar
alcohols such as xylitol and cyclamate. NHDC usage boosts the effects
of these sweeteners at lower concentrations than would otherwise
be required; smaller amounts of other sweeteners are needed. This
provides a cost benefit.
As a flavour enhancer, NHDC is used in a wide range of products
and is indicated by the E number E 959. It is noted particularly
for enhancing sensory effects (known in the industry as 'mouth feel.')
An example of this is 'creaminess' in dairy foods such as yogurt
and ice cream but is also widely favoured for use in otherwise naturally
bitter products. Pharmaceutical companies are fond of the product
as a means of reducing the bitterness of pharmacological drugs in
tablet form and it has been used for livestock feed as a means of
reducing feeding time. Other products NHDC can be found in may include
a wide variety of alcoholic beverages (and non-alcoholic), savoury
foods, toothpaste, mouthwash and condiments such as ketchup and
mayonnaise.
NHDC in pure form is found as a white substance not unlike powdered
sugar. In food it is used as a flavour enhancer in concentrations
of around 4-5 parts per million (ppm) and as an artificial sweetener
at around 15-20 ppm.
Research has shown that at strengths of around and above 20ppm,
NHDC can produce side effects such as nausea and migraine. This
is not widely documented, however is unquestionably known within
the food science communities that have worked with the product,
and many recommend wearing a surgical mask when handling pure NHDC.
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