Nutritional Supplement Helps Ease Depression
Adding the nutritional supplement SAMe to common antidepressants
may help depressed patients who haven't responded to single-drug
the conclusion of a Massachusetts General Hospital study in the
December issue of the Journal of Clinical Psychopharmacology.
The study found that treatment with both SAMe and an antidepressant
either improved or completely relieved depression symptoms in the
majority of patients.
SAMe (S-Adenosy-L-Methionine) is a substance found in every human
cell and is a commonly used dietary supplement, the researchers
This study included 30 people who continued to have significant
depression after more than a month of treatment with antidepressants
such as Prozac, Effexor and Paxil. Over the six-week study, the
patients took SAMe along with their antidepressant.
The patients started by taking 400 milligrams of SAMe two times
a day. After two weeks, that was increased to 800 milligrams of
SAMe two times a day. At the end of the study, half the patients
had significant improvement in their symptoms and 43 percent had
complete remission of their depression.
The study was funded by Pharmavite LLC, which makes nutritional
supplements and vitamins.
The researchers noted that the study had many limitations. It was
a small study that lacked a control group and the subjects knew
they were taking an active dose of SAMe.