Question
Moderators: Boss Man, cassiegose
Re: Question
To knowledge Guarana is a Caffeine carrier.
Creatine might have some kind of Vasodilating effect, when combined with an NO product, as NO vasodilates, however if you look at something NO-explode, it has Caffeine in it.
The points to consider in this are three.
1. More Caffeine than NO, leading to potentially a slightly reduced Vasoconstriction effect from the competition of NO with Caffeine.
2. Equal amounts possible causing no significant effect either way.
3. More NO than Caffeine, meaning Caffeine NO competition, creates a reduced Vasodilation effect.
Whilst I cannot say all three things are set in stone, logically they make sense.
Caffeine doesn't necessarily cause dehydration. However through resrcting bloodvessels and stimulating the heart, any associated rise in Thermogenic reactions through caffeinated activity, compared to activity without Caffeine, would increase sweating potential, and also as Caffeine is a Methylxanthine, the Xanthines can convert to Uric Acid, (a Gout cause), which is only dealt with in vivo, by water stores. It has no enzymatic reaction to break it down or metabolise it.
So if the body decided to sweat more, from Caffeine induced thermogenic increases and / or use more water to remove Uric Acid, you might either retard Creatine effects, or possibly cause a slight increase of side effects, owing to the reduction of water for use in Creatine metabolism.
Plus, as you would be sweating Oxygen molecules in the water, any ability for the body to aerobically use Pyruvate from the end stage of the Glycolytic pathway, could result in a reduced ability to use enough Pyruvate, for creation of a Krebs Cycle precursor, (said cycle, a key way of dealing with Creatine), because Pyruvate minus Oxygen, can create for one thing Lactic Acid.
So Caffeine would have it's negative effects per se on Creatine, but as Guarana I'm pretty sure has Caffeine in it, it would do something to potentially interfere with Creatine, not directly but indirectly by affecting some of the necessary processes, in relation to Water and Oxygen use in the body.
Creatine might have some kind of Vasodilating effect, when combined with an NO product, as NO vasodilates, however if you look at something NO-explode, it has Caffeine in it.
The points to consider in this are three.
1. More Caffeine than NO, leading to potentially a slightly reduced Vasoconstriction effect from the competition of NO with Caffeine.
2. Equal amounts possible causing no significant effect either way.
3. More NO than Caffeine, meaning Caffeine NO competition, creates a reduced Vasodilation effect.
Whilst I cannot say all three things are set in stone, logically they make sense.
Caffeine doesn't necessarily cause dehydration. However through resrcting bloodvessels and stimulating the heart, any associated rise in Thermogenic reactions through caffeinated activity, compared to activity without Caffeine, would increase sweating potential, and also as Caffeine is a Methylxanthine, the Xanthines can convert to Uric Acid, (a Gout cause), which is only dealt with in vivo, by water stores. It has no enzymatic reaction to break it down or metabolise it.
So if the body decided to sweat more, from Caffeine induced thermogenic increases and / or use more water to remove Uric Acid, you might either retard Creatine effects, or possibly cause a slight increase of side effects, owing to the reduction of water for use in Creatine metabolism.
Plus, as you would be sweating Oxygen molecules in the water, any ability for the body to aerobically use Pyruvate from the end stage of the Glycolytic pathway, could result in a reduced ability to use enough Pyruvate, for creation of a Krebs Cycle precursor, (said cycle, a key way of dealing with Creatine), because Pyruvate minus Oxygen, can create for one thing Lactic Acid.
So Caffeine would have it's negative effects per se on Creatine, but as Guarana I'm pretty sure has Caffeine in it, it would do something to potentially interfere with Creatine, not directly but indirectly by affecting some of the necessary processes, in relation to Water and Oxygen use in the body.